| inns & 455 runs | v Hampshire | Old Trafford, Manchester | 1911 | f8312 |
| inns & 452 runs | v Somerset | County Ground, Taunton | 1895 | f4300 |
| inns & 348 runs | v Derbyshire | The Park, Buxton | 1975 | f30593 |
| inns & 330 runs | v Kent | Angel Ground, Tonbridge | 1892 | f3761 |
| inns & 291 runs | v Kent | Old Trafford, Manchester | 1895 | f4240 |
| inns & 273 runs | v Leicestershire | Old Trafford, Manchester | 1912 | f8502 |
| inns & 271 runs | v Middlesex | Old Trafford, Manchester | 1882 | f2571 |
| inns & 248 runs | v Somerset | Old Trafford, Manchester | 1910 | f7949 |
| inns & 228 runs | v Derbyshire | Old Trafford, Manchester | 1920 | f9645 |
| inns & 228 runs | v Durham | Riverside Ground, Chester-le-Street | 2005 | f48727 |
| inns & 220 runs | v Derbyshire | County Ground, Derby | 1897 | f4638 |
| inns & 220 runs | v Glamorgan | Whitegate Park, Blackpool | 1923 | f10577 |
| inns & 214 runs | v Derbyshire | Old Trafford, Manchester | 1926 | f11518 |
| inns & 212 runs | v Essex | Old Trafford, Manchester | 1937 | f15760 |
| inns & 210 runs | v Oxford University | Old Trafford, Manchester | 1883 | f2630 |
| inns & 200 runs | v Northamptonshire | Emirates Old Trafford, Manchester | 2014 | f55685 |
| inns & 197 runs | v Glamorgan | Old Trafford, Manchester | 1922 | f10151 |
| inns & 194 runs | v Leicestershire | Old Trafford, Manchester | 1924 | f10940 |
| inns & 192 runs | v Worcestershire | County Ground, New Road, Worcester | 1934 | f14611 |
| inns & 188 runs | v Nottinghamshire | Trent Bridge, Nottingham | 1895 | f4259 |
| inns & 187 runs | v Sussex | Old Trafford, Manchester | 1890 | f3514 |
| inns & 186 runs | v Sussex | County Ground, Hove | 1897 | f4787 |
| inns & 185 runs | v Surrey | Old Trafford, Manchester | 1909 | f7745 |
| inns & 184 runs | v Derbyshire | County Ground, Derby | 1901 | f5659 |
| inns & 184 runs | v Glamorgan | Cardiff Arms Park, Cardiff | 1923 | f10540 |
| inns & 183 runs | v Worcestershire | War Memorial Ground, Amblecote | 1909 | f7651 |
| inns & 181 runs | v Worcestershire | Old Trafford, Manchester | 1912 | f8592 |
| inns & 180 runs | v Kent | Bat and Ball Ground, Gravesend | 1891 | f3666 |
| inns & 177 runs | v Essex | Valentine's Park, Ilford | 1938 | f16095 |
| inns & 175 runs | v Middlesex | Lord's Cricket Ground, St John's Wood | 1995 | f41752 |
| inns & 173 runs | v Somerset | Old Trafford, Manchester | 1957 | f21819 |
| inns & 170 runs | v Leicestershire | Grace Road, Leicester | 1899 | f5162 |
| inns & 169 runs | v Gloucestershire | Old Trafford, Manchester | 1919 | f9443 |
| inns & 167 runs | v Worcestershire | County Ground, New Road, Worcester | 1900 | f5396 |
| inns & 160 runs | v Derbyshire | Old Trafford, Manchester | 1883 | f2608 |
| inns & 160 runs | v Derbyshire | Queen's Park, Chesterfield | 1920 | f9575 |
| inns & 160 runs | v Hampshire | County Ground, Southampton | 1938 | f16078 |
| inns & 159 runs | v Somerset | Old Trafford, Manchester | 1934 | f14528 |
| inns & 158 runs | v Oxford University | The University Parks, Oxford | 1951 | f19072 |
| inns & 157 runs | v Somerset | Old Trafford, Manchester | 1882 | f2494 |
| inns & 157 runs | v Leicestershire | Emirates Old Trafford, Manchester | 2015 | f56435 |
| inns & 157 runs | v Glamorgan | Penrhyn Avenue, Rhos-on-Sea, Colwyn Bay | 2015 | f56477 |
| inns & 153 runs | v Kent | Old Trafford, Manchester | 1914 | f9119 |
| inns & 153 runs | v Essex | County Ground, Leyton | 1926 | f11700 |
| inns & 153 runs | v Sussex | Old Trafford, Manchester | 1951 | f19223 |
| inns & 150 runs | v Somerset | Old Trafford, Manchester | 1905 | f6660 |
| inns & 150 runs | v Derbyshire | Queen's Park, Chesterfield | 1926 | f11690 |
| inns & 150 runs | v Glamorgan | Penrhyn Avenue, Rhos-on-Sea, Colwyn Bay | 2019 | f59570 |