| 304* | T de Zorzi | v Free State | PPC Newlands, Cape Town | 2022/23 | f61238 |
| 271* | JE Cheetham | v Orange Free State | Ramblers Cricket Club Ground, Bloemfontein | 1950/51 | f18976 |
| 261* | SSL Steyn | v Border | Newlands, Cape Town | 1929/30 | f12957 |
| 250* | AG Puttick | v Griqualand West | Newlands, Cape Town | 2003/04 | f47841 |
| 244 | G Kirsten | v Border | Buffalo Park, East London | 1995/96 | f42104 |
| 244 | G Kirsten | v Eastern Province | Newlands, Cape Town | 2001/02 | f46418 |
| 229* | AG Puttick | v Boland | BOE Park, Paarl | 2001/02 | f46105 |
| 220 | AI Paine | v Griqualand West | Old Wanderers, Johannesburg | 1896/97 | f4622 |
| 219* | AW Nourse | v Natal | Newlands, Cape Town | 1932/33 | f14107 |
| 217* | JD Nel | v Eastern Province | St George's Park, Port Elizabeth | 1952/53 | f19857 |
| 214* | SA Engelbrecht | v Namibia | Wanderers Cricket Ground, Windhoek | 2012/13 | f54778 |
| 211* | PJ Malan | v Namibia | Sparta Cricket Club Ground, Walvis Bay | 2016/17 | f57301 |
| 208* | DPB Morkel | v Natal | Newlands, Cape Town | 1929/30 | f12962 |
| 206* | AJ Lamb | v Northern Transvaal | Newlands, Cape Town | 1992/93 | f40168 |
| 204* | PN Kirsten | v Natal | Newlands, Cape Town | 1986/87 | f36596 |
| 204* | PJ Malan | v Boland | Boland Park, Paarl | 2016/17 | f57398 |
| 203 | HH Gibbs | v KwaZulu-Natal | Kingsmead, Durban | 2002/03 | f46812 |
| 202* | MH Austen | v Eastern Province | Newlands, Cape Town | 1987/88 | f37376 |
| 202* | DL Haynes | v Eastern Province | St George's Park, Port Elizabeth | 1996/97 | f42827 |
| 202* | HD Ackerman | v Northerns | Supersport Centurion, Centurion | 1997/98 | f43647 |
| 202* | MZ Hamza | v Namibia | Wanderers Cricket Ground, Windhoek | 2014/15 | f55779 |
| 201 | LD Ferreira | v North West | North West Cricket Stadium, Potchefstroom | 2000/01 | f45676 |
| 201* | K Verreynne | v Boland | PPC Newlands, Cape Town | 2022/23 | f61227 |
| 200* | JB Commins | v Griqualand West | Kimberley Country Club, Kimberley | 1996/97 | f42856 |
